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Antigenic Specificity | CD305 (LAIR-1), Human |
Clone | REA447 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD305 (LAIR-1) Antibody, anti-human, PE, REAfinity™. Clone REA447 recognizes the human CD305 antigen, a single-pass type I membrane protein which is also known as leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1). CD305 contains a single extracellular immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. It is structurally related to several other inhibitory Ig superfamily members. CD305 is expressed on almost all immune cells, including NK cells, T cells, B cells, monocytes, monocyte-derived dendritic cells, eosinophils, basophils, and mast cells. Besides being expressed on differentiated peripheral blood cells, the receptor is also present on CD34+ hematopoietic progenitor cells and on the majority of thymocytes. Cross-linking of CD305 on human NK cells delivers a potent inhibitory signal that is capable of inhibiting target cell lysis by resting and activated NK cells. Furthermore, CD305 can inhibit the cytotoxic activity of effector T cells upon CD3 cross-linking or antigen stimulation. In primary B cells, CD305 cross-linking leads to decreased BCR-induced calcium mobilization and down-regulation of Ig and cytokine production. | Additional information: Clone REA447 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | hLAIR1, CD305, LAIR-1 |
Gene, Accession # | Gene ID: 3903 |
Catalog # | 130-126-118 |
Price | $119 |
Order / More Info | CD305 (LAIR-1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Meyaard, L. et al. (1997) LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. Immunity 7 (2): 283-290. | Meyaard, L. (2008) The inhibitory collagen receptor LAIR-1 (CD305). J. Leukoc. Biol. 83 (4): 799-803. | Perbellini, O. et al. (2014) Clinical significance of LAIR1 (CD305) as assessed by flow cytometry in a prospective series of patients with chronic lymphocytic leukemia. Haematologica 99 (5): 881-887. |