Edit |   |
---|---|
Antigenic Specificity | TCRγ/δ, Human |
Clone | REA591 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | Vio Bright V423 conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TCRγ/δ Antibody, anti-human, Vio® Bright V423, REAfinity™. Clone REA591 recognizes the human TCRγ/δ antigen. The T cell receptor is a heterodimeric glycoprotein associated with the CD3 antigen. It consists of an α and a β chain (TCRα/β) or a γ and a δ chain (TCRγ/δ). The γ and δ TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. The γ chain forms either disulfide-linked or non-disulfide-linked heterodimers with the δ-subunit. The γ/δ T cell receptor is present on a subset of T lymphocytes in peripheral blood. TCRγ/δ is involved in the antigen recognition of tumor-associated antigens or bacterial antigens presented by MHC class I molecules. | Additional information: Clone REA591 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | TCRgd |
Gene, Accession # | Gene ID: 6965 |
Catalog # | 130-128-272 |
Price | $176 |
Order / More Info | TCRγ/δ, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Airoldi, I. et al. (2015) γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes. Blood 125 (15): 2349-2358. | Bonneville, M. et al. (2010) Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity. Nat. Rev. Immunol. 10 (7): 467-478. | Wiest, D. L. (2016) Development of γδ T cells, the special-force soldiers of the immune system. Methods Mol. Biol. 1323: 23-32. |