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Antigenic Specificity | CD318 (CDCP1), Human |
Clone | REA194 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | allophycocyanin (APC) conjugate |
Size | 30 tests in 300 µL |
Concentration | 1:11 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD318 (CDCP1) Antibody, anti-human, APC, REAfinity™. Clone REA194 recognizes CD318, a type I transmembrane protein which is also known as CUB domain-containing protein 1 (CDCP1) or SIMA135. CD318 has an approximate molecular weight of 93 kDa and contains an extracellular domain with three regions with low homology to complement protein subcomponents C1r/C1s, urchin embryonic growth factor, and bone morphogenetic protein 1 (CUB) domains. CD318 has been suggested to be an interacting partner of Src family kinase and protein kinase Cδ. It has been shown that CD318 plays a role in cancer progression and the development of metastases. CD318 expression is found widely in normal tissues, whereas an aberrant overexpression is suggested to be associated with tumor cells. | Additional information: Clone REA194 displays negligible binding to Fc receptors. | |
Immunogen | n/a |
Other Names | CDCP1, SIMA135, TRASK |
Gene, Accession # | Gene ID: 64866 |
Catalog # | 130-101-208 |
Price | $142 |
Order / More Info | CD318 (CDCP1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Liu, H. et al. (2011) CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis. Proc. Natl. Acad. Sci. U.S.A. 108: 1379-1384. | Conze, T. et al. (2003) CDCP1 is a novel marker for hematopoietic stem cells. Ann. N. Y. Acad. Sci. 996: 222-226. | Scherl-Mostageer, M. et al. (2001) Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Oncogene 20 (32): 4402-4408. |