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Antigenic Specificity | CD140b, Human |
Clone | REA363 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | Vio Bright B515 conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD140b Antibody, anti-human, Vio® Bright B515, REAfinity™. Clone REA363 recognizes the human CD140b antigen, a single-pass type I membrane protein, also known as platelet-derived growth factor receptor beta (PDGFR-β). CD140b is broadly expressed in embryonic tissue and in cells of mesodermal origin in adult tissue as fibroblasts, smooth muscle cells, glial cells, and chondrocytes. It is a tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis, and migration. | Additional information: Clone REA363 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | PDGFRB, IBGC4, IMF1, JTK12, Pdgfr, PDGFR-1 |
Gene, Accession # | Gene ID: 5159 |
Catalog # | 130-131-577 |
Price | $208 |
Order / More Info | CD140b, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Gronwald, R. G. et al. (1988) Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class. Proc. Natl. Acad. Sci. U.S.A. 85 (10): 3435-3439. | Jin, S. et al. (2008) Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells. Circ. Res. 102 (12): 1483-1491. | Ball, S. G. et al. (2012) Inhibition of platelet-derived growth factor receptor signaling regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency. Stem Cells 30 (3): 548-560. | Chi, S. et al. (2016) A CRISPR-based toolbox for studying T cell signal transduction. Biomed Res Int 2016: . |