Chromogranin A, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Chromogranin A, Human |
| Clone | REAL1033 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | phycoerythrin (PE) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Chromogranin A Antibody, anti-human, PE, REAdye_lease™. Clone REAL1033 is an antibody fragment derived from the full Chromogranin A antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity | Clone REAL1033 recognizes Chromogranin A, also known as parathyroid secretory protein 1, CHGA or CgA. Chromogranin A is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It functions as a precursor of different peptides such as vasostatin 1 and 2, catestatin, pancreastatin or parastatin and modulates the formation of secretory vesicles. It is detected in secretory vesicles of neurons and in several endocrine tissues including the adrenal medulla, pituitary, paraganglia, beta cells of pancreas, thyroid, and parathyroid. It is used as a marker for carcinoid tumors, insulinoma, pheochromocytomas, medullary thyroid carcinoma, paragangliomas, neuroblastoma and other neuro-endocrine tumors. Increasing Chromogranin A levels can also lead to non-malignant diseases such as gastrointestinal, cardiovascular and inflammatory diseases. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
| Immunogen | n/a |
| Other Names | Chromogranin-A, CgA, CHGA |
| Gene, Accession # | n/a |
| Catalog # | 130-127-832 |
| Price | $460 |
| Order / More Info | Chromogranin A, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Fischer-Colbrie, R. et al. (1985) Immunological studies on the distribution of chromogranin A and B in endocrine and nervous tissues . Neuroscience 16 (3): 547-555. | Cotesta, D. et al. (2005) High plasma levels of human chromogranin A and adrenomedullin in patients with pheochromocytoma. Tumori 91 (1): 53-58. | Lyubimova, N. V. et al. (2016) Chromogranin As a Biochemical Marker of Neuroendocrine Tumors. Bull Exp Biol Med 160 (5): 702-704. | Raoof , M. et al. (2019) Prognostic significance of Chromogranin A in small pancreatic neuroendocrine tumors. Surgery 165 (4): 760-766. | Mahata, S. K. et al. (2019) Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation. Ann. N. Y. Acad. Sci. 1455 (1): 34-58. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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