Edit |   |
---|---|
Antigenic Specificity | CD192 (CCR2), Human |
Clone | REA264 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | Vio Bright V423 conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD192 (CCR2) Antibody, anti-human, Vio® Bright V423, REAfinity™. Clone REA264 recognizes the CD192 antigen, a G-protein-linked seven transmembrane receptor which is also known as C-C chemokine receptor type 2 (CCR2) or monocyte chemoattractant protein 1 receptor (MCP-1-R). Two spliced variants of CD192 (CD192A and CD192B) are expressed on peripheral monocytes and basophils as a result of alternate splicing of a single gene and differ at the C-terminal end. CD192 and its main ligand CCL2 have been implicated in a wide range of immunobiological processes and neuropathologies, including recruitment of monocytes and regulation of bone marrow homeostasis, as well as multiple sclerosis, HIV-associated dementia, Alzheimer's disease, and neuropathic pain. | Additional information: Clone REA264 displays negligible binding to Fc receptors. | |
Immunogen | n/a |
Other Names | CCR2, CC-CKR-2, CCR-2A, CCR2B, Ckr2, CKR2A, Ckr2b, Cmkbr2, MCP-1-R |
Gene, Accession # | Gene ID: 1231 |
Catalog # | 130-130-925 |
Price | $208 |
Order / More Info | CD192 (CCR2), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Charo, I. F. et al. (1994) Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc. Natl. Acad. Sci. U.S.A. 91 (7): 2752-2756. | Henrich, T. J. et al. (2013) HIV-1 entry inhibitors: recent development and clinical use. Curr. Opin. Virol. 3 (1): 51-57. |