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Antigenic Specificity | CD8a, Human |
Clone | REA1024 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | fluorescein (FITC) conjugate |
Size | 200 µL |
Concentration | 1:50 |
Applications | MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD8a Antibody, anti-human, FITC, REAfinity™. Clone REA1024 recognizes the human CD8 antigen, a cell-surface glycoprotein, also known as Leu-2 or CD8a. CD8 is strongly expressed on human cytotoxic T cells and thymocytes, and on a subset of NK cells. The CD8 antigen is a disulfide-linked dimer that exists either as a CD8a homodimer or as a CD8α/β heterodimer. CD8 acts as a coreceptor for the T cell receptor and binds to the MHC Class I molecules. CD8 is involved in T cell development and activation of mature T cells. The CD8 antibody recognizes the α-subunit of the antigen. | Additional information: Clone REA1024 displays negligible binding to Fc receptor. |
Immunogen | n/a |
Other Names | Leu-2, CD8a, MAL, p32, Cd8b1, LY3, Lyt3, P37, Ly-2 |
Gene, Accession # | Gene ID: 925 |
Catalog # | 130-117-200 |
Price | $270 |
Order / More Info | CD8a, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Devine, L. et al. (1999) Orientation of the Ig domains of CD8 alpha beta relative to MHC class I. J Immunol 162 (2): 846-851. | Gao, G. F. et al. (2000) Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunol. Today 21 (12): 630-636. |