DLL4, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | DLL4, Mouse |
| Clone | REA1105 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PE-Vio 615 conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | DLL4 Antibody, anti-mouse, PE-Vio® 615, REAfinity™. Clone REA1105 recognizes the mouse DLL4, which is one of the six identified Notch ligands in vertebrates. Being a canonical Notch ligand, extracellular domain of DLL4 contains N-terminal domain, delta/serrate/LAG-2 (DSL) domain, and tandemly arranged multiple EGF-like repeats. Binding of canonical ligands such as DLL4 induces cleavage and release of Notch intracellular domain (NICD), followed by its translocation in the nucleus where it interacts with transcription factors involved in induction of expression of Notch target genes. As a ligand for Notch1, DLL4 is the first Notch ligand to be expressed during mouse development. DLL4 plays an important role in developmental angiogenesis. In mice, lack of a single DLL4 allele leads to early embryonic lethality characterized by severe defects in arterial differentiation and vascular remodeling. | Additional information: Clone REA1105 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Delta4 |
| Gene, Accession # | Gene ID: 54485 |
| Catalog # | 130-119-258 |
| Price | $167 |
| Order / More Info | DLL4, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Duarte, A. et al. (2004) Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev. 18: 2474 -2478. | Krebs, L. T. et al. (2004) Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev. 18: 2469 -2473. | D'Souza, B. et al. (2010) Canonical and non-canonical Notch ligands. Curr Top Dev Biol. 92: 73-129. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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