Notch1, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Notch1, Mouse |
| Clone | 22E5 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2aκ |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Notch1 Antibody, anti-mouse, APC. Notch1 is a 300 kDa member of the Notch family of type I transmembrane glycoproteins. Following cleavage in the Golgi, Notch forms a heterodimer composed of a 180-200 kDa disulfide-linked extracellular domain, and a 120 kDa membrane-bound intracellular portion. Upon ligand binding the latter is cleaved to form the notch intracellular domain transcription factor. Notch signaling controls cell fate decisions and is involved in multiple cellular differentiation steps during embryonic development and in adult organisms. In the immune system, Notch1 plays a non-redundant role for thymic T cell development 1). Notch1 is also expressed by peripheral T cells and upregulated upon T cell activation 2). The 22E5 antibody reacts with the extracellular part of the murine Notch1 protein. |
| Immunogen | n/a |
| Other Names | Mis6, N1, TAN-1, lin-12 |
| Gene, Accession # | Gene ID: 18128 |
| Catalog # | 130-102-266 |
| Price | $88 |
| Order / More Info | Notch1, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Fiorini, E. et al. (2009) Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. J Immunol 183 (11): 7212-7222. | Radtke, F. et al. (2010) Notch signaling in the immune system. Immunity 32 (1): 14-27. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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