HLA-DM, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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|---|---|
| Antigenic Specificity | HLA-DM, Human |
| Clone | REAL549 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | fluorescein (FITC) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | HLA-DM Antibody, anti-human, FITC, REAdye_lease™. Clone REAL549 is an antibody fragment derived from the full HLA-DM antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL549 recognizes the human HLA-DM antigen, a non-classical MHC Class II molecule (MHC II) chaperone that works in lysosomes and endosomes. MHC II molecules are transmembrane glycoproteins which function by binding processed antigenic peptides and presenting them to CD4+ T lymphocytes to initiate or maintain a specific immune response. Constitutive MHC II expression is restricted to professional antigen presenting cells including dendritic cells, B cells, and macrophages and to the epithelial cells of the thymus. A high HLA-DM expression is found in lymph nodes, the spleen, and bone marrow. Functional class II expression is highly dependent on the expression of two main chaperones, the invariant chain (Ii) and DM. Newly synthesized class II α- and β-chains form a nonameric complex with three Ii molecules in the endoplasmic reticulum where Ii blocks the peptide-binding groove and guides class II dimers to the endocytic pathway where Ii is proteolytically cleaved leaving the CLIP fragment bound to class II. HLA-DM, an endocytic chaperone, protects empty class II dimers until they bind a peptide capable to confer enough stability to the complex. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
| Immunogen | n/a |
| Other Names | MHC class II antigen HLA-DM |
| Gene, Accession # | n/a |
| Catalog # | 130-122-267 |
| Price | $390 |
| Order / More Info | HLA-DM, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Oldford, S. A. et al. (2006) Tumor cell expression of HLA-DM associates with a T?1 profile and predicts improved survival in breast carcinoma patients. Int. Immunol. 18 (11): 1591-1602. | van Lith, M. et al. (2010) HLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM. J. Biol. Chem. 285 (52): 40800-40808. | Pos, W. et al. (2013) Mechanisms of peptide repertoire selection by HLA-DM. Trends Immunol. 34 (10): 495-501. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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