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Antigenic Specificity | CD35, Human |
Clone | E11 |
Host Species | Mouse |
Reactive Species | human, nonhuman primate |
Isotype | IgG1κ |
Format | PE-Vio 770 conjugate |
Size | 100 tests in 1 mL |
Concentration | 1:11 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD35 Antibody, anti-human, PE-Vio® 770. The monoclonal antibody E11 recognizes the human cell surface protein CD35, the C3b/C4b receptor, also known as CR1 or complement receptor type I. Four CD35 allotypes with different molecular weights are known; 190, 220, 250, and 280 kDa. CD35 is expressed on hematopoietic cells such as granulocytes, monocytes, B cells, subsets of natural killer (NK) and T cells, erythrocytes, and follicular dendritic cells (DCs). Known functions of CD35 include transport of C3 complexes on erythrocytes, complement activation, phagocytosis, and inhibition of the activation-induced proliferation of T and B cells. |
Immunogen | n/a |
Other Names | CR1, C3BR, C4BR, KN, C3b/C4b-R |
Gene, Accession # | Gene ID: 1378 |
Catalog # | 130-100-006 |
Price | $350 |
Order / More Info | CD35, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Reilly, B. et al. (2010) Human peripheral CD4+ T-cells expressing complement receptor 1 (CR1, CD35). J Immunol 184 (1 Supplement): 138.3. | Reynes, M. et al. (1985) Human follicular dendritic cells express CR1, CR2, and CR3 complement receptor antigens. J Immunol 135: 2687-2694. | Klickstein, L. B. et al. (1988) Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis. J. Exp. Med. 168: 1699-1717. |