53BP1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | 53BP1, Human |
| Clone | REAL1211 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | phycoerythrin (PE) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | 53BP1 Antibody, anti-human, PE, REAdye_lease™. Clone REAL1211 is an antibody fragment derived from the full 53BP1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1211 recognizes the human 53BP1 (tumor protein p53 binding protein 1), a Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. It promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). | |
| Immunogen | n/a |
| Other Names | TP53-binding protein 1, TP53BP1, tumor protein p53 binding protein 1, p53-binding protein 1, p53BP1 |
| Gene, Accession # | n/a |
| Catalog # | 130-130-617 |
| Price | $454 |
| Order / More Info | 53BP1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Lottersberger, F. et al. (2013) Role of 53BP1 oligomerization in regulating double-strand break repair. Proc. Natl. Acad. Sci. U.S.A. 110 (6): 2146-2151. | Callen, E. et al. (2013) 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell 153 (6): 1266-1280. | Noordermeer, S. M. et al. (2018) The shieldin complex mediates 53BP1-dependent DNA repair. Nature 560 (7716): 117-121. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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