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Antigenic Specificity | CD3, Human |
Clone | OKT3 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2aκ |
Format | purified |
Size | 100 µg in 1 mL |
Concentration | n/a |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Immunocytochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD3 Antibody, anti-human, pure-functional grade. The CD3 antibody recognizes the human CD3 antigen which is present on mature human T cells, thymocytes, and NKT cells. The epitope recognized by the antibody is located on the ε-chain of the CD3 complex. Clone OKT3 has been shown to activate T cell function. | Activation and proliferation of T cells can be induced by interaction of the T cell receptor with peptide-MHC complexes expressed on the surface of antigen-presenting cells (APCs). The T cell receives a signal transduced through the CD3 complex. Cytokines or other costimulatory signals are required in addition. Activated T cells can be used for any downstream processes, such as cytokine analysis or immunoprecipitation. Cells can also be transfected with high efficiency. |
Immunogen | n/a |
Other Names | CD3e, IMD18, T3E, TCRE |
Gene, Accession # | Gene ID: 915, 916, 917 |
Catalog # | 130-093-387 |
Price | $212 |
Order / More Info | CD3, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Lecureuil, C. et al. (2007) Trapping and apoptosis of novel subsets of memory T lymphocytes expressing CCR6 in the spleen of HIV-infected patients. Blood 109: 3649-3657. |