JAK2/3 (Phospho-Tyr966/939) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | JAK2/3 (Phospho-Tyr966/939) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.03 mL, 0.1 mL, 0.2 mL |
| Concentration | 1 mg/ml |
| Applications | Western Blot (WB), Immunocytochemistry (ICC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects endogenous levels of JAK2/3 when Phospho occurs at Tyr966/939(human) or Tyr966/935(mouse/rat), It doesn't react with total protein. JAK2 is a kinase that is misregulated or mutated in a number of myeloproliferative diseases and cancers. The mutation V617F is the most clinically relevant variant, and is seen in around half of myeloproliferative disorders. The variant is a known activating mutation, and activated JAK2 is sufficient to drive myeloproliferative disorders in mouse models. V617F, while most recurrent, is not the only mechanism by which JAK2 can be activated in patients. JAK2 is now one of the first diagnostic markers tested upon diagnosis with a myeloproliferative disorder. |
| Immunogen | Immunogen: Synthesized peptide derived from part region of human JAK2/3 (Phospho-Tyr966/939) Antibody protein at amino acid sequence of T966 |
| Other Names | [Rabbit JAK2/3 (Phospho-Tyr966/939); Tyrosine-protein kinase JAK2/JAK3; Janus kinase 2/Janus kinase 3; JAK-2/JAK-3] |
| Gene, Accession # | [JAK2/3], Gene ID: 3717, NCBI: NP_004963.1, UniProt: O60674 |
| Catalog # | MBS9709552 |
| Price | $130, $220, $325 |
| Order / More Info | JAK2/3 (Phospho-Tyr966/939) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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