Phospho-PRAS40 (Ser183) Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Phospho-PRAS40 (Ser183) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Phospho-PRAS40 (Ser183) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Phospho-PRAS40 (Ser183) antibody detects endogenous levels of PRAS40. Function: Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphoryla |
| Immunogen | Immunogen: A synthesized peptide derived from human PRAS40 around the phosphorylation site of Ser183. Subcellular Location: Cytoplasm > Cytosol. Found in the cytosolic fraction of the brain. Tissue Specificity: Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A-549 and HeLa) than in normal cell lines (e.g. HEK293). Predicted Cross Reactivity: Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Xenopu |
| Other Names | [40 kDa proline rich AKT substrate; 40 kDa proline-rich AKT substrate; AKT1 S1; AKT1 substrate 1 (proline rich); AKT1 substrate 1; AKT1S 1; AKT1S1; AKTS1_HUMAN; Lobe; MGC2865; PRAS 40; PRAS; PRAS40; Proline rich akt substrate; Proline rich Akt substrate 40 kDa; Proline-rich AKT1 substrate 1] |
| Gene, Accession # | [PRAS40], Gene ID: 84335, NCBI: NP_001092102.1, UniProt: Q96B36 |
| Catalog # | MBS9600714 |
| Price | $240, $280 |
| Order / More Info | Phospho-PRAS40 (Ser183) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
Return to Antibodies