Edit |   |
---|---|
Antigenic Specificity | Human ADAM-10 |
Clone | [6D39] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The monoclonal antibody reacts with human CD156c, which is also known as a disintegrin and metalloproteinase domain-containing protein (ADAM) 10. This type I transmembrane glycoprotein is expressed ubiquitously on hematopoietic and non-hematopoietic cell types. Studies demonstrate that CD156c expression is regulated by PAX2 in cancer cells. CD156c plays a critical role in hematopoiesis, including lymphocyte development, and autoimmunity by regulating the shedding and secretion of various receptors and chemokines, including Notch, CD23, CXCL16, and the IL-6R. Finally, deregulated CD156c expression has been associated with T-cell acute lymphoblastic lymphoma (T-ALL) and Alzheimer's disease. |
Immunogen | Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with Human ADAM-10 (extracellular domain) recombinant protein. |
Other Names | [ADAM10; kuz; AD10; MADM; CD156c; HsT18717], [ADAM10; ADAM10; RAK; kuz; AD10; AD18; MADM; CD156c; HsT18717; KUZ; MADM; ADAM 10] |
Gene, Accession # | [ADAM-10], Gene ID: 102, NCBI: NP_001101.1, UniProt: O14672 |
Catalog # | MBS690006 |
Price | $475 |
Order / More Info | Human ADAM-10 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |