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Antigenic Specificity | MICU1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cy |
Immunogen | Immunogen: Recombinant Human Calcium uptake protein 1, mitochondrial protein (55-191AA) |
Other Names | [Calcium uptake protein 1, mitochondrial; Atopy-related autoantigen CALC1; MICU1; CALC1 Publication] |
Gene, Accession # | [MICU1], Gene ID: 10367, NCBI: NP_001182447.1, UniProt: Q9BPX6 |
Catalog # | MBS7108555 |
Price | $160, $235 |
Order / More Info | MICU1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |