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Antigenic Specificity | OTUD7B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: OTUD7B antibody detects endogenous levels of OTUD7B. Function: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal |
Immunogen | Immunogen: A synthesized peptide derived from human OTUD7B. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells. Predicted Cross Reactivity: Pig, Bovine, Sheep, Dog Similarity: Pig (100%), Bovine (100%), Sheep (100%), Dog (100%) |
Other Names | [Cellular zinc finger NF kappa B protein; Cellular zinc finger NF-kappa-B protein; CEZANNE; HGNC:16683; OTU domain containing protein 7B; OTU domain-containing protein 7B; OTU7B_HUMAN; OTUD7B; ZA20D1; Zinc finger A20 domain containing protein 1; Zinc finger A20 domain-containing protein 1; Zinc finger protein Cezanne] |
Gene, Accession # | [OTUD7B], Gene ID: 56957, NCBI: NP_064590.2, UniProt: Q6GQQ9 |
Catalog # | MBS9603446 |
Price | $240, $280 |
Order / More Info | OTUD7B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |