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Antigenic Specificity | PAR1 |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: PAR1 antibody detects endogenous levels of total PAR1. Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.Post-translational Modifications: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor.Similarity: The cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor peptide known as parstatin. Belongs to the G-protein coupled receptor 1 family. |
Immunogen | Immunogen: Purified recombinant fragment of human PAR1 expressed in E. Coli Subcellular Location: Cell Membrane Tissue Specificity: Platelets and vascular endothelial cells. |
Other Names | [CF2R; Coagulation factor II (thrombin) receptor; Coagulation factor II receptor; F2R; HTR; PAR 1; PAR-1; PAR1; PAR1_HUMAN; Protease activated receptor 1; Proteinase activated receptor 1; Proteinase-activated receptor 1; Thrombin receptor; TR] |
Gene, Accession # | [PAR1], Gene ID: 2149, NCBI: NP_001298242.1, UniProt: P25116 |
Catalog # | MBS9602651 |
Price | $235, $295, $370 |
Order / More Info | PAR1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |