Lymphotoxin alpha [3F12.2D3] Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Lymphotoxin alpha [3F12.2D3] |
| Clone | [3F12.2D3] |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | IgG, kappa |
| Format | Protein A purified |
| Size | 0.2 mg |
| Concentration | 1 mg/ml |
| Applications | Neutralization, ELISA (EIA), Flow Cytometry (FC/FACS), Surface Plasmon Resonance (SPR) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: 3F12 binds to human LTalpha3 and LTalphabeta (with a KD of ~0.3 nM, determined by BIACORE; ~ 37 pM, determined by ELISA) in both its soluble homotrimeric and membrane heterotrimeric forms. LTalpha belongs to the tumor necrosis factor (TNF) superfamily and is secreted as a homo-trimer (LTalpha3), or is expressed on the cell surface in complex with LTbeta. Lymphotoxin is produced by lymphocytes and in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. LTalpha3 signaling induces target cells to upregulate many chemokines and cytokines in an NFkB-dependent manner. Recombinant monoclonal antibody to Lymphotoxin alpha. Manufactured using a proprietary Recombinant Platform with variable regions (i.e. spec |
| Immunogen | Immunogen: 3F12 was prepared by hyperimmunizing BALB/c mice with purified recombinant human LTalpha expressed in E. coli-the hybridoma clone was selected for its ability to bind LTalpha3 by ELISA. The CDRs of the antibody were grafted to the framework regions of the mice mAb 2G7 to create the chimeric version of the antibody. |
| Other Names | [chimeric 3F12; LT; LTalpha3; Tumor necrosis factor beta; Tumor necrosis factor beta; Tumor necrosis factor-beta; tumor necrosis factor-beta; TNF beta; TNF-beta; TNF beta; TNF-beta; Lymphotoxin-alpha; Lymphotoxin alpha], [LTA; LTA; LT; TNFB; TNFSF1; TNLG1E; TNFB; TNFSF1; LT-alpha] |
| Gene, Accession # | [LTalpha], Gene ID: 4049, NCBI: NP_000586.2, UniProt: P01374 |
| Catalog # | MBS488355 |
| Price | $425 |
| Order / More Info | Lymphotoxin alpha [3F12.2D3] Antibody from MYBIOSOURCE INC. |
| Product Specific References | Catellana et al. Resurrection of a Clinical Antibody: Template ProteoGenomic de novoProteomic Sequencing and Reverse Engineering of an Anti-Lymphotoxin Alpha Antibody Proteomics. 2011 Feb; 11(3): 395-405. PMID:21268269 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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