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Antigenic Specificity | UBA1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). |
Immunogen | Immunogen: Recombinant Human Ubiquitin-like modifier-activating enzyme 1 protein (730-881AA) |
Other Names | [Ubiquitin-like modifier-activating enzyme 1; Protein A1S9; Ubiquitin-activating enzyme E1; UBA1; A1S9T; UBE1] |
Gene, Accession # | [UBA1], Gene ID: 7317, NCBI: NP_003325.2, UniProt: P22314 |
Catalog # | MBS7104753 |
Price | $160, $235 |
Order / More Info | UBA1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |