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Antigenic Specificity | CD61/Integrin '3/Platelet Glycoprotein IIIa (Platelet Marker) |
Clone | polyclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the V-chain (CD51) to form vitronectin receptor, or with the IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61).The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic |
Immunogen | Immunogen: Recombinant human ITGB3 protein fragment (aa 385-490) (exact sequence is proprietary) |
Other Names | [BDPLT2; GP3A; GPIIIa; GT; HPA 1; HPA 4; Integrin beta-3; ITGB3; NAIT; Platelet fibrinogen receptor beta subunit; Platelet glycoprotein IIIa; PTP] |
Gene, Accession # | [ITGB3], Gene ID: 3690, NCBI: NP_000203.2, UniProt: P05106 |
Catalog # | MBS4381031 |
Price | $190, $340, $340 |
Order / More Info | CD61/Integrin '3/Platelet Glycoprotein IIIa (Platelet Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Gatter KC., et al. Histopathology 1988; 13:257-67 |