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Antigenic Specificity | PPP1R8 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing. A synthetic peptide, NIPP-1(330-351), is able to inhibit PP-1. Phosphorylation of Tyr-335 reduces PP-1 inhibition, whereas phosphorylation of Thr-346 or Ser-34 |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-209 of human PPP1R8 (NP 612568.1). |
Other Names | [ARD1; ARD-1; NIPP1; NIPP-1; PRO2047] |
Gene, Accession # | [PPP1R8], NCBI: NP_002704.1, UniProt: Q12972 |
Catalog # | MBS8546302 |
Price | $280 |
Order / More Info | PPP1R8 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |