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Antigenic Specificity | APPBP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, ratpredicted: porcine, zebrafish, bovine, horse, sheep, rabbit, dog, chicken |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: APPBP1 Antibody detects endogenous levels of APPBP1. Description: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.Post Translational Modifications: Ubiquitinated by TRIP12, leading to its degradation by the proteasome.Subunit Structure: Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M |
Immunogen | Immunogen: A synthesized peptide derived from human APPBP1. Tissue Specificity: Ubiquitous in fetal tissues. Expressed throughout the adult brain. |
Other Names | [59 kDa; A 116A10.1; Amyloid beta precursor protein binding protein 1 59kD; Amyloid beta precursor protein binding protein 1 59kDa; Amyloid beta precursor protein binding protein 1; Amyloid beta precursor protein binding protein 1, 59 kDa; Amyloid beta precursor protein-binding protein 1; Amyloid protein binding protein 1; Amyloid protein-binding protein 1; APP BP1; APP-BP1; APPBP 1; APPBP1; HPP 1; HPP1; NAE 1; NAE1; NEDD8 activating enzyme E1 regulatory subunit; NEDD8 activating enzyme E1 subunit 1; NEDD8 activating enzyme E1 subunit; NEDD8-activating enzyme E1 regulatory subunit; Proto oncogene protein 1; Proto-oncogene protein 1; Protooncogene protein 1; ula 1; ULA1_HUMAN] |
Gene, Accession # | [APPBP1], Gene ID: 8883, NCBI: Q13564.1, UniProt: Q13564 |
Catalog # | MBS9611578 |
Price | $240, $280 |
Order / More Info | APPBP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |