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Antigenic Specificity | PKC alpha |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates a |
Immunogen | Immunogen: A synthesized peptide derived from human PKC alpha. Subcellular Localization: Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Nucleus. |
Other Names | [Protein kinase C alpha type; PKC-A; PKC-alpha; 2.7.11.13; PRKCA; PKCA; PRKACA], [PRKCA] |
Gene, Accession # | [PKC alpha], Gene ID: 5578, NCBI: NP_002728.1, UniProt: P17252 |
Catalog # | MBS179435 |
Price | $160, $340, $340 |
Order / More Info | PKC alpha Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |