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Antigenic Specificity | BLK (B lymphoid tyrosine kinase) |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | ascites |
Size | 0.1 mL |
Concentration | 1ug/ul |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | BLK (B lymphoid tyrosine kinase), with 505-amino acid protein (about 56KDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR. |
Immunogen | Immunogen: Ni-NTA purified truncated recombinant BLK expressed in E Coli strain BL21 (DE3) |
Other Names | [B lymphoid tyrosine kinase; Tyrosine-protein kinase Blk; tyrosine-protein kinase Blk; BLK proto-oncogene, Src family tyrosine kinase; B lymphocyte kinase; p55-Blk], [BLK; BLK; MODY11] |
Gene, Accession # | [BLK], Gene ID: 640, NCBI: AAH32413.1 |
Catalog # | MBS418366 |
Price | $445 |
Order / More Info | BLK (B lymphoid tyrosine kinase) Antibody from MYBIOSOURCE INC. |
Product Specific References | 1.Theresa Tretter, Ashley E. Ross, Dominic I. Dordai J. Exp. Med., Dec 2003; 198: 1863. |