APP (Center), 333-362 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | APP (Center), 333-362 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Immunofluorescence (IF), ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333-362 amino acids from the Central region of human APP. This gene encodes a cell surface receptor andtransmembrane precursor protein that is cleaved by secretases toform a number of peptides. Some of these peptides are secreted andcan bind to the acetyltransferase complex APBB1/TIP60 to promotetranscriptional activation, while others form the protein basis ofthe amyloid plaques found in the brains of patients with Alzheimerdisease. Mutations in this gene have been implicated in autosomaldominant Alzheimer disease and cerebroarterial amyloidosis(cerebral amyloid angiopathy). Multiple transcript variantse |
| Immunogen | n/a |
| Other Names | [Amyloid beta A4 protein; ABPP; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II; N-APP; Soluble APP-alpha; S-APP-alpha; Soluble APP-beta; S-APP-beta; C99; Beta-amyloid protein 42; Beta-APP42; Beta-amyloid protein 40; Beta-APP40; C83; P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59; Amyloid intracellular domain 59; AICD-59; AID(59); Gamma-CTF(59); Gamma-secretase C-terminal fragment 57; Amyloid intracellular domain 57; AICD-57; AID(57); Gamma-CTF(57); Gamma-secretase C-terminal fragment 50; Amyloid intracellular domain 50; AICD-50; AID(50); Gamma-CTF(50); C31; APP; A4; AD1] |
| Gene, Accession # | [APP], Gene ID: 351, NCBI: NP_000475.1, UniProt: P05067 |
| Catalog # | MBS9203335 |
| Price | $165, $370 |
| Order / More Info | APP (Center), 333-362 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Dahse, K., et al. J. Mol. Biol. 403(4):643-659(2010) Hare, J. Biochem. Biophys. Res. Commun. 401(2):219-224(2010) Vossel, K.A., et al. Science 330 (6001), 198 (2010) : Singh, T.D., et al. FEBS Lett. 584(18):3936-3942(2010) Crews, L., et al. J. Neurosci. 30(37):12252-12262(2010) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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