Edit |   |
---|---|
Antigenic Specificity | GP6 (C-term), 309-337 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This GP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-337 amino acids from the C-terminal region of human GP6. Glycoprotein VI (GP6) is a 58-kD platelet membraneglycoprotein that plays a crucial role in the collagen-inducedactivation and aggregation of platelets. Upon injury to the vesselwall and subsequent damage to the endothelial lining, exposure ofthe subendothelial matrix to blood flow results in deposition ofplatelets. Collagen fibers are the most thrombogenic macromolecularcomponents of the extracellular matrix, with collagen types I, III,and VI being the major forms found in blood vessels. Plateletinteraction with collagen occurs as a 2-step procedur |
Immunogen | n/a |
Other Names | [Platelet glycoprotein VI; GPVI; Glycoprotein 6; GP6] |
Gene, Accession # | [GP6], Gene ID: 51206, NCBI: NP_001242946.1, UniProt: Q9HCN6 |
Catalog # | MBS9211313 |
Price | $165, $370 |
Order / More Info | GP6 (C-term), 309-337 Antibody from MYBIOSOURCE INC. |
Product Specific References | Polgar, J., et al. J. Biol. Chem. 272(21):13576-13583(1997) Asselin, J., et al. Blood 89(4):1235-1242(1997) Huang, M.M., et al. Proc. Natl. Acad. Sci. U.S.A. 88(17):7844-7848(1991) Moroi, M., et al. J. Clin. Invest. 84(5):1440-1445(1989) |