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Antigenic Specificity | GRB14 (N-Term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein A purified |
Size | 0.05 mL, 0.2 mL |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This GRB14 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 14-48 amino acids from the human region of human GRB14. Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. |
Immunogen | n/a |
Other Names | [Growth factor receptor-bound protein 14; GRB14 adapter protein; GRB14] |
Gene, Accession # | [GRB14], Gene ID: 2888, NCBI: NP_004481.2, UniProt: Q14449 |
Catalog # | MBS9231345 |
Price | $165, $370 |
Order / More Info | GRB14 (N-Term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Daly R.J.,et al.J. Biol. Chem. 271:12502-12510(1996). Ota T.,et al.Nat. Genet. 36:40-45(2004). Hillier L.W.,et al.Nature 434:724-731(2005). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Bereziat V.,et al.J. Biol. Chem. 277:4845-4852(2002). |