GRB14 (N-Term) Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityGRB14 (N-Term)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
FormatProtein A purified
Size0.05 mL, 0.2 mL
Concentrationn/a
ApplicationsFlow Cytometry (FC/FACS), Western Blot (WB), ELISA (EIA)
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DescriptionThis GRB14 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 14-48 amino acids from the human region of human GRB14. Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Immunogenn/a
Other Names[Growth factor receptor-bound protein 14; GRB14 adapter protein; GRB14]
Gene, Accession #[GRB14], Gene ID: 2888, NCBI: NP_004481.2, UniProt: Q14449
Catalog #MBS9231345
Price$165, $370
Order / More InfoGRB14 (N-Term) Antibody from MYBIOSOURCE INC.
Product Specific ReferencesDaly R.J.,et al.J. Biol. Chem. 271:12502-12510(1996). Ota T.,et al.Nat. Genet. 36:40-45(2004). Hillier L.W.,et al.Nature 434:724-731(2005). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Bereziat V.,et al.J. Biol. Chem. 277:4845-4852(2002).
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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