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Antigenic Specificity | Heat shock protein 60, HSP60 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Heat shock protein 60 (HSP60) in the matrix of mitochondria is essential for the folding and assembly of newly imported proteins. Hsp60 belongs to a class of structurally related chaperonins found in organelles of endosymbiotic origin and in the bacterial cytosol.1 Members of the chaperonin class include the Escherichia coli, groEL protein and the Rubisco subunit-binding protein of chloroplasts.2 In both prokaryotic and eukaryotic systems, synthesis of these proteins is induced in response to stresses, such as heat shock.3 Under normal physiological conditions, HSP60 is a 60 KD oligomer composed of monomers that form a complex arranged as two stacked heptameric rings.1 HSP60 may be a very useful marker for patients with superficial bladder |
Immunogen | Immunogen: A synthetic peptide (conjugated to KLH) corresponding to 320 aa residues of human HSP60. |
Other Names | [Heat shock protein 60; HSP60], [HSP60; CPN60; heat shock protein 60; HEAT SHOCK PROTEIN 60-3B; HSP60; HSP60-3B] |
Gene, Accession # | [HSP60], Gene ID: 821983, NCBI: NP_189041.1, UniProt: P29197 |
Catalog # | MBS355057 |
Price | $275 |
Order / More Info | Heat shock protein 60, HSP60 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Cheng MY, Hartl FU, Horwich AL (November 1990). The mitochondrial chaperonin hsp60 is required for its own assembly. Nature 348 (6300): 455-8. 2. Cheng, M. Y., Hartl, F.-U., Martin, J., Pollock, R. A., Kalousek, F., Neupert, W., Hallberg, E. M., Hallberg, R. L., Horwich, A. L. Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature 337: 620-625, 1989. 3. Venner, T. J., Singh, B., Gupta, R. S. Nucleotide sequences and novel structural features of human and Chinese hamster hsp60 (chaperonin) gene families. DNA Cell Biol. 9: 545-552, 1990. 4. Lebret T, Watson RW, Molinie V, et al. (September 2003). Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma. Cancer 98 (5): 970-7. |