CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityCPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker)
Clone[CPS1/1022]
Host SpeciesMouse
Reactive Specieshuman, dog
IsotypeIgG1
Formatunconjugated
Size0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml)
Concentrationn/a
ApplicationsImmunofluorescence (IF), Immunohistochemistry (IHC) Formalin
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DescriptionThis MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCCs occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for
ImmunogenImmunogen: Recombinant human CPS1 protein
Other Names[Carbamoyl-phosphate synthetase 1 (CPS1); Carbamoylphosphate synthetase 1; CPSase 1; CPSASE1], [CPS1; CPS1; PHN; CPSASE1; CPSase I]
Gene, Accession #[CPS1], Gene ID: 1373, NCBI: NP_001116105.1, UniProt: P31327
Catalog #MBS439459
Price$190, $340, $340
Order / More InfoCPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Antibody from MYBIOSOURCE INC.
Product Specific ReferencesHaraguchi, Y., et al. 1991. Cloning and sequence of a cDNA encoding human carbamyl phosphate synthetase I: molecular analysis of hyperam- monemia. Gene 107: 335-340. Ramos-Vara, J.A., et al. Histochem 2002; J. 34: 397-401. Fan, Z., et al. Mod. Pathol 2003; 16: 137-144, 2003.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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