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Antigenic Specificity | CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) |
Clone | [CPS1/1022] |
Host Species | Mouse |
Reactive Species | human, dog |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCCs occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for |
Immunogen | Immunogen: Recombinant human CPS1 protein |
Other Names | [Carbamoyl-phosphate synthetase 1 (CPS1); Carbamoylphosphate synthetase 1; CPSase 1; CPSASE1], [CPS1; CPS1; PHN; CPSASE1; CPSase I] |
Gene, Accession # | [CPS1], Gene ID: 1373, NCBI: NP_001116105.1, UniProt: P31327 |
Catalog # | MBS439459 |
Price | $190, $340, $340 |
Order / More Info | CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Haraguchi, Y., et al. 1991. Cloning and sequence of a cDNA encoding human carbamyl phosphate synthetase I: molecular analysis of hyperam- monemia. Gene 107: 335-340. Ramos-Vara, J.A., et al. Histochem 2002; J. 34: 397-401. Fan, Z., et al. Mod. Pathol 2003; 16: 137-144, 2003. |