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Antigenic Specificity | TSC22D3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-79 of human TSC22D3 (NP 001015881.1). |
Other Names | [DIP; GILZ; DSIPI; TSC-22R] |
Gene, Accession # | [TSC22D3], Gene ID: 1831, NCBI: NP_001015881.1, UniProt: Q99576 |
Catalog # | MBS8546368 |
Price | $280 |
Order / More Info | TSC22D3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |