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Antigenic Specificity | AATF |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases. AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways. Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the beta-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic l |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 12 amino acid peptide from near the carboxy terminus of human AATF. |
Other Names | [Apoptosis antagonizing transcription factor, Che-1] |
Gene, Accession # | [AATF], Gene ID: 26574, NCBI: NP_036270 |
Catalog # | MBS9412722 |
Price | $320 |
Order / More Info | AATF Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |