LAT, phosphorylated (Tyr132) (Linker for activation of T Cells) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | LAT, phosphorylated (Tyr132) (Linker for activation of T Cells) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 10 Blots |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes human LAT when phosphorylated at Tyr132. Species sequence homology: mouse (85%) and rat (77%). Linker for activation of T cells (LAT) is a 36kD transmembrane adapter protein that is tyrosine-phosphorylated following T-cell receptor (TCR) stimulation by ZAP-70 and Syk. Four distal tyrosine residues (Y132, Y171, Y191 and Y226 in human LAT) are crucial for its activity and subsequent signaling to downstream molecules. Tyrosine 132 mediates LAT binding to PLC-y-1 and is necessary for TCR-mediated calcium mobilization and activation of ERK and NFAT proteins. |
| Immunogen | Immunogen: Synthetic phosphopeptide derived from a region of human LAT that contains tyrosine132. |
| Other Names | [-LAT, phosphorylated (Tyr132) (Linker for activation of T Cells)], [LAT; LAT; LAT1; pp36] |
| Gene, Accession # | Gene ID: 27040, UniProt: O43561 |
| Catalog # | MBS629009 |
| Price | $635 |
| Order / More Info | LAT, phosphorylated (Tyr132) (Linker for activation of T Cells) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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