GBL Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | GBL |
| Clone | [211CT7.1.1] |
| Host Species | Mouse |
| Reactive Species | mouse |
| Isotype | IgG1,k |
| Format | ascites |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This GBL monoclonal antibody is generated from mouse immunized with GBL recombinant protein. Subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Amino-acid-signaling to mTORC1 is mediated by Rag GTPases, which cause amino-acid-induced relocalization of mTOR within the endomembrane system. Growth factor-stimulated mTORC1 activation involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome sy |
| Immunogen | n/a |
| Other Names | [Target of rapamycin complex subunit LST8; TORC subunit LST8; G protein beta subunit-like; Gable; Protein GbetaL; Mammalian lethal with SEC13 protein 8; mLST8; MLST8; GBL; LST8] |
| Gene, Accession # | [MLST8], Gene ID: 64223, NCBI: NP_001186102.1, UniProt: Q9BVC4 |
| Catalog # | MBS9200151 |
| Price | $370 |
| Order / More Info | GBL Antibody from MYBIOSOURCE INC. |
| Product Specific References | Ali, S.M., et al. J. Biol. Chem. 280(20):19445-19448(2005) Inoki, K., et al. Microbiol. Mol. Biol. Rev. 69(1):79-100(2005) Sarbassov, D.D., et al. Science 307(5712):1098-1101(2005) Jacinto, E., et al. Nat. Cell Biol. 6(11):1122-1128(2004) Kim, D.H., et al. Mol. Cell 11(4):895-904(2003) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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