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Antigenic Specificity | CYLD (Human) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.025 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes human CYLD. The tumor suppressor CYLD is a deubiquitinylating enzyme (DUB) that antagonises NF-kappaB and JNK signaling by disassembly of Lys63-linked ubiquitin chains synthesised in response to cytokine stimulation. The DUB activity of CYLD is mediated by its C-terminal ubiquitin specific protease (USP) domain, pathogenic truncations and mutations of which are associated with the hypertrophic skin tumor cylindromatosis through disruption of the USP domain and subsequent loss of CYLD catalytic activity. |
Immunogen | Immunogen: Synthetic peptide corresponding to aa 336-353 of human CYLD. |
Other Names | [Probable ubiquitin carboxyl-terminal hydrolase CYLD], [CYLD; CYLD; EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2; CYLD1; KIAA0849] |
Gene, Accession # | [CYLD], Gene ID: 1540, NCBI: Q9NQC7.1, UniProt: Q9NQC7 |
Catalog # | MBS565171 |
Price | $200 |
Order / More Info | CYLD (Human) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |