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Antigenic Specificity | MAPK7 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: MAPK7 Antibody detects endogenous levels of total MAPK7. ERK5 (Mitogen-activated protein kinase 7, Big mitogen-activated protein kinase 1) is a member of the MAPK superfamily implicated in the regulation numerous cellular processes including proliferation, differentiation, and survival (1, 5-7). Like other MAPK family members, ERK5 contains a canonical activation loop TEY motif (Thr218/Tyr220) which is specifically phosphorylated by MAP2K5 (MEK5) in a growth factor-dependent, Ras-independent mechanism (2-4). For example, EGF stimulation promotes ERK5 phosphorylation which induces its traslocation to the nucleus where it phosphorylates MEF2C and other transcriptional targets (2, 3). ERK5 is also activated in response to granuloc |
Immunogen | Immunogen: Recombinant protein of human MAPK7 |
Other Names | [BMK1; ERK4; ERK5; PRKM7] |
Gene, Accession # | [MAPK7], Gene ID: 5598, NCBI: NP_002740.2, UniProt: Q13164 |
Catalog # | MBS8516305 |
Price | $290 |
Order / More Info | MAPK7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |