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Antigenic Specificity | Amyloid Beta Peptide 42 |
Clone | [CA9 3B3] |
Host Species | Mouse |
Reactive Species | human, other primates, mouse, rat. The antibody does not cross react with amyloid beta peptide 40 in dot blotting and ELISA. cross-reactivity to amyloid beta peptide 43 is about 5% in ELISA. |
Isotype | IgG2b,k |
Format | Protein G purified |
Size | 0.5 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes the C-terminal sequence (MVGGVVIA) of Abeta42 and full length Abeta42. Beta amyloid peptide 42. Amyloid beta peptide 42 (A~42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. A~42 and A~40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. A~42 (42 amino acids) is very fibrillogenic. The beta pleated structure of A~42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that A~42 contributes to the pathogenesis of Alzheimer's disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheime |
Immunogen | Immunogen: KLH conjugated to a short peptide (MVGGVVIA) with amino acid sequence corresponding to the C-terminal of Abeta42. Myeloma: Sp2/0-Ag14. Light Chain: Kappa. |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS592140 |
Price | $445 |
Order / More Info | Amyloid Beta Peptide 42 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |