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Antigenic Specificity | ZAP70 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: ZAP70 Antibody detects endogenous levels of total ZAP70. The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement (1). Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck (2-6). Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. Expression of Zap-70 is correlated with disease progression and survival in patients with chronic lymphocytic leukemia (7, 8). |
Immunogen | Immunogen: Recombinant protein of human ZAP70 |
Other Names | [FLJ17670; FLJ17679; SRK; STD; TZK; ZAP-70] |
Gene, Accession # | [ZAP70], Gene ID: 7535, NCBI: NP_001070.2, UniProt: P43403 |
Catalog # | MBS8516388 |
Price | $290 |
Order / More Info | ZAP70 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |