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Antigenic Specificity | PA26 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: PA26 Polyclonal Antibody detects endogenous levels of PA26 protein. SESN1 encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The sestrin 1 mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
Immunogen | Immunogen: Synthesized peptide derived from the internal region of human PA26 at AA rangle: 240-320 |
Other Names | [Rabbit PA26; SESN1; PA26; SEST1; Sestrin-1; p53-regulated protein PA26] |
Gene, Accession # | [PA26], Gene ID: 27244, NCBI: NP_001186862.1, UniProt: Q9Y6P5 |
Catalog # | MBS9705188 |
Price | $130, $220, $325 |
Order / More Info | PA26 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |