Phospho-Ser316 NF-kappaB p65 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Ser316 NF-kappaB p65 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse. predicted: bovine, dog, goat, hamster, porcine, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Specific for endogenous levels of the~65 kDa NF-kappaB p65 protein phosphorylated at Ser316. Immunolabeling is nearly eliminated with Lambda-Ptase treatment. p65, also known as RelA, is one of the five members of the NF-kappaB family. The p65 and p50 heterodimer is the predominant form of NF-kappaB, where p65 is the major subunit (Gilmore et al, 2006). There have been 13 identified phosphorylation sites on p65, including ser316 which is induced by IL-1beta (Viatour et al, 2005 and Wang et al, 2015). Phosphorylation of ser316 is essential for NF-kappaB nuclear transportation, NF-kappaB-dependent gene regulation, cytokine/chemokine secretion, and other biological functions (Wang et al, 2015). Ser316 has also been demonstrated to |
| Immunogen | Immunogen Species: Mouse. Immunogen Information: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser316 conjugated to KLH. |
| Other Names | [NF-kB p65 (Ser316)], [Rela; Rela; p65; p65 NFkB; p65 NF-kappa B; Nfkb3] |
| Gene, Accession # | [RELA], Gene ID: 19697, NCBI: NP_033071.1, UniProt: Q04207 |
| Catalog # | MBS500087 |
| Price | $360 |
| Order / More Info | Phospho-Ser316 NF-kappaB p65 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Gilmore, TD (2006) Introduction to NF-kappaB: players, pathways, perspecitives. Oncogene 25, 6680-6684. 2. Viatour P, Merville, MP, Bours V, Chariot A. (2005) Phosphorylation of NF- kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem. Sci. 30, 43-52. 3. Wang B, Wei H, Prabhu L, Zhao W, Martin M, Hartley AV, and Lu T. (2015) Role of Novel Serine 316 Phosphorylation of the p65 Subunit of NF-kappaB in Differential Gene Regulation. J Biol Chem, 290(33):20336-47. 4. Price, MA. (2006) CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling. Gene Dev. 20, 399-410. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
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