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Antigenic Specificity | TNFRSF10B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 56-210 of human TNFRSF10B (NP 003833.4). |
Other Names | [DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5] |
Gene, Accession # | [TNFRSF10B], Gene ID: 8795, NCBI: NP_003833.4, UniProt: O14763 |
Catalog # | MBS8544334 |
Price | $280 |
Order / More Info | TNFRSF10B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |