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Antigenic Specificity | SYK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Syk is a protein tyrosine kinase that plays an important role in intracellular signal transduction in hematopoietic cells (1-3). Syk interacts with immunoreceptor tyrosine-based activation motifs (ITAMs) located in the cytoplasmic domains of immune receptors (4). It couples the activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis (4). There is also evidence of a role for Syk in nonimmune cells, and investigators have indicated that Syk is a potential tumor suppressor in human breast carcinomas (5). Tyr323 is a negative regulatory phosphorylation site within the SH2-kinase linker region in Syk. Phosphorylation of Tyr323 provides a direct b |
Immunogen | Immunogen: Recombinant protein of human SYK Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [DKFZp313N1010; FLJ25043; FLJ37489] |
Gene, Accession # | [SYK], Gene ID: 6850, NCBI: NP_001128524.1, UniProt: P43405 |
Catalog # | MBS8503891 |
Price | $310 |
Order / More Info | SYK Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Cheng, A.M. and Chan, A.C. (1997) Curr. Opin. Immunol. 9, 528-533. 2. Kurosaki, T. et al. (1997) Curr. Opin. Immunol. 9, 309-318. 3. Chu, D.H. et al. (1998) Immunol. Rev. 165, 167-180. 4. Turner, M. et al. (2000) Immunol. Today 21, 148-154. 5. Coopman, P.J. et al. (2000) Nature 406, 742-747. 6. Deckert, M. et al. (1998) J. Biol. Chem. 273, 8867-8874. 7. Rao, N. et al. (2001) EMBO J. 20, 7085-7095. 8. Law, C.L. et al. (1996) Mol. Cell. Biol. 16, 1305-1315. 9. Zhang, J. et al. (2000) J. Biol. Chem. 275, 35442-35447. |