Edit |   |
---|---|
Antigenic Specificity | Human ATG12 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Peptide Affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | ATG12 (autophagy-related protein 12), also known as APG12, is a 140 amino acid protein that is ubiquitously expressed and belongs to the ATG12 family of proteins. ATG12 is a homolog of the yeast protein APG12 that participates in autophagy. Autophagy is a membrane trafficking mechanism that delivers cytoplasmic cargo to the vacuole/lysosome for degradation and recycling. In yeast, autophagy requires a protein conjugation system consisting of APG12 covalently bound at the carboxy terminal glycine to lysine 149 of APG5. Similarly in humans, ATG12 is essential for autophagy and localizes to the cytoplasm where it is covalently bound to APG5, a conjugation reaction that requires APG7, ATG10 and ATP (1-3). The ATG12-APG5 conjugate functions as a |
Immunogen | Immunogen: Synthetic peptide from the N-terminal of human ATG12. Immunogen Species: Human |
Other Names | [APG12-like; APG12; ATG12_Human; HAPG12; FBR93; ATG12 : Streptavidin; Rabbit Human ATG12; Rabbit Human ATG12; ATG12], [ATG12; ATG12; APG12; FBR93; APG12L; HAPG12; APG12; APG12L; APG12-like] |
Gene, Accession # | [ATG12], Gene ID: 9140, NCBI: NP_001264712.1, UniProt: O94817 |
Catalog # | MBS807397 |
Price | $435 |
Order / More Info | Human ATG12 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Mizushima N., Sugita H., Yoshimori T., Ohsumi Y. (1999) J Biol Chem. 273(51): 33889-33892. 2. Mizushuma N., et al. (1998) Nature. 395: 395-398. 3. Suzuki K., et al. (2001) EMBO J. 20: 5971-5981. |