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Antigenic Specificity | CDC2 |
Clone | [3H10-D8-B3] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | ascites |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein k |
Immunogen | Immunogen: Purified recombinant fragment of CDC2 expressed in E. Coli. |
Other Names | [CDC2; CDC28A; P34CDC2; MGC111195; DKFZp686L20222; CDK1] |
Gene, Accession # | [CDC2], Gene ID: 983, NCBI: NP_001777.1, UniProt: P06493 |
Catalog # | MBS8538621 |
Price | $280 |
Order / More Info | CDC2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |