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Antigenic Specificity | USP5 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human USP5 (NP 003472.2). |
Other Names | [ISOT] |
Gene, Accession # | [USP5], Gene ID: 8078, NCBI: P45974.2, UniProt: P45974 |
Catalog # | MBS8545346 |
Price | $280 |
Order / More Info | USP5 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |