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Antigenic Specificity | SIVA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFk-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 16 amino acid peptide near the amino terminus of human SIVA. |
Other Names | [SIVA1, apoptosis-inducing factor, CD27-binding protein, CD27BP, SIVA-1, SIVA-2] |
Gene, Accession # | [SIVA], Gene ID: 10572, NCBI: NP_068355 |
Catalog # | MBS9410954 |
Price | $320 |
Order / More Info | SIVA Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |