CD180, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CD180, Human |
| Clone | MHR73 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | F, Flow Cytometry (FC/FACS), FS, Immunoprecipitation (IP), P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody MHR73 reacts with human RP105 (CD180). RP105 is a type 1 transmembrane protein of 105 kDa with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. RP105 expression is largely restricted to immune cells including CD19 B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (MHR73) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule CD80, revealing RP105 as a potent regulator of B-cell activation. In this context it is imp |
| Immunogen | n/a |
| Other Names | [CD180 antigen; CD180 antigen; CD180 antigen; lymphocyte antigen 64; radioprotective 105 kDa protein; lymphocyte antigen-64, radioprotective, 105kDa; CD180 molecule; Lymphocyte antigen 64; Radioprotective 105 kDa protein; CD_antigen: CD180], [CD180; CD180; LY64; Ly78; RP105; LY64; RP105] |
| Gene, Accession # | [CD180], Gene ID: 4064, NCBI: NP_005573.2 |
| Catalog # | MBS584155 |
| Price | $420 |
| Order / More Info | CD180, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Miura Y, et al; RP105 is associated with MD-1 and transmits an activation signal in human B cells. Blood 1998, 92: 2815 2. Tsuneyoshi, N et al; The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1. J Immunol 2005, 174: 340 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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