GCK (C-term), 403-433 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | GCK (C-term), 403-433 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 2 |
| Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This GCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 403-433 amino acids from the C-terminal region of human GCK. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of the gene for GCK results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in the gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), |
| Immunogen | n/a |
| Other Names | [Glucokinase; Hexokinase type IV; HK IV; Hexokinase-4; HK4; Hexokinase-D; GCK] |
| Gene, Accession # | [GCK], Gene ID: 2645, NCBI: NP_000153.1, UniProt: P35557 |
| Catalog # | MBS9210736 |
| Price | $165, $370 |
| Order / More Info | GCK (C-term), 403-433 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Gloyn, A.L., et al., Diabetes 52(9):2433-2440 (2003). Pruhova, S., et al., Diabetologia 46(2):291-295 (2003). Rizzo, M.A., et al., J. Biol. Chem. 277(37):34168-34175 (2002). Cao, H., et al., Hum. Mutat. 20(6):478-479 (2002). Barrio, R., et al., J. Clin. Endocrinol. Metab. 87(6):2532-2539 (2002). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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