PTX3, Human Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | PTX3, Human |
| Clone | MNB4 |
| Host Species | Rat |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | F, Flow Cytometry (FC/FACS), Immunoassay (IA), Immunofluorescence (IF), Immunoprecipitation (IP), P, Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody MNB4 (previously known as clone 20) recognizes human pentraxin 3 (PTX3), belonging to the long pentraxin family. PTX3 is an acute-phase glycoprotein of ~45 kDa with glycosylation accounting for about 10% of its molecular weight. PTX3 has a complex oligomeric structure with protomers linked to each other by disulfide bonds. PTX3 expression is triggered by inflammatory cytokines, resulting in higher levels of circulating PTX3. Several cell types have been reported to produce PTX3, namely macrophages, endothelial cells, neutrophils and synoviocytes. PTX3 is involved in host defense against pathogen infection, in the regulation of the scavenger activity of macrophages and dendritic cells, and in modu |
| Immunogen | Immunogen: Human recombinant PTX3 |
| Other Names | [Pentraxin-related protein PTX3, Tumor necrosis factor-inducible gene 14 protein, TSG-14], [PTX3; PTX3; TSG-14; TNFAIP5; TNFAIP5; TSG14; TNF alpha-induced protein 5; TSG-14] |
| Gene, Accession # | [PTX3], Gene ID: 5806, NCBI: NP_002843.2 |
| Catalog # | MBS584258 |
| Price | $520 |
| Order / More Info | PTX3, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Peri, G et al; PTX3, a prototypical long pentraxin, is an early indicator of acute myocardial infarction in humans. Circulation 2000, 102: 636 2. Fazzini, F et al; PTX3 in small-vessel vasculitides: an independent indicator of disease activity produced at sites of inflammation. Arthritis Rheum 2001, 44: 2841 3. Bussolati, B et al; The long pentraxin Ptx3 is synthesized in IgA glomerulonephritis and activates mesangial cells. J immunol 2003, 170: 1466 4. Inforzato, A et al; Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation. Biochemistry 2006, 45: 11540 5. Jaillon, S et al; The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med 2007, 204: 793 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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